Clinical Islet Xenotransplantation: A Step Forward
نویسندگان
چکیده
منابع مشابه
Clinical Islet Xenotransplantation: A Step Forward
Article history: Received 21 September 2016 Accepted 21 September 2016 Available online 24 September 2016 (n= 4) or 10,000 IEq/kg × 2 (n= 4) of encapsulated neonatal porcine islets in their peritoneal cavity by laparoscopy. Although the study demonstrated significant improvement in HbA1c and reduction of hypoglycemic unawareness events with an improved transplant estimated function (TEF) score ...
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Type 1 diabetes (T1D) is a major health problem throughout the world. In the U.S., it is estimated that about 1.5 million people suffer from T1D. Even when well controlled—by frequent monitoring of blood glucose and administration of insulin, the long-term complications of the disease are significant and include cardiovascular disease, nephropathy, retinopathy, and neuropathy (1). Here we revie...
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License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be f...
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Tilapia, a teleost fish species with large anatomically discrete islet organs (Brockmann bodies; BBs) that can be easily harvested without expensive and fickle islet isolation procedures, make an excellent donor species for experimental islet xenotransplantation research. When transplanted into streptozotocin-diabetic nude or severe combined immunodeficient mice, BBs provide long-term normoglyc...
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Four clinical trials of porcine islet transplantation have been reported, and there are verbal reports that clinical trials on much larger scales are continuing in centers in China and Russia. The four reported trials are briefly reviewed and, in the light of the present status of experimental islet xenotransplantation, consideration is given to whether such trials are currently justified. The ...
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ژورنال
عنوان ژورنال: EBioMedicine
سال: 2016
ISSN: 2352-3964
DOI: 10.1016/j.ebiom.2016.09.023